dawnmedDawnMed Journal of Medical ScienceISVolume 2, Issue 1MultidisciplinaryEnglish2026NNY2025056Internal MedicineA 50-Year-Old Female with Hypertension Revealing Cushing’s Disease: A Case ReportEnglishY14KhaledMejahed¹EnglishNAbdel-QaderFakhr¹EnglishYKhalidSalman²EnglishYSalmaEmad¹EnglishYAyham F.Reweey²EnglishYHypertension is a common condition frequently managed in primary care. However, secondary causes such as Cushing’s syndrome may be overlooked, leading to delays in diagnosis and treatment. We present the case of a 50-year-old female with a 5-year history of hypertension who presented for routine medication adjustment. A systematic clinical assessment revealed features suggestive of hypercortisolism. Subsequent biochemical testing confirmed Cushing’s disease, and MRI imaging revealed a pituitary adenoma with associated visual field defects, previously unnoticed by the patient. This case highlights the importance of comprehensive evaluation in hypertensive patients to identify secondary causes and prevent complications.EnglishHypertension; Cushing; Case report; Pituitary.https://dawnmed.com.sa/abstract?id=2References1619Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. Hypertension. 2018;71(6):e13-e115.Funder JW, Carey RM, Mantero F, et al. The management of primary aldosteronism: Case detection, diagnosis, and treatment: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(5):1889-916.Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushingand;rsquo;s syndrome. Lancet. 2006;367(9522):1605-17.Nieman LK. Cushingand;rsquo;s syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol. 2015;173(4):M33-38.Lacroix A, Feelders RA, Stratakis CA, Nieman LK. Cushingand;rsquo;s syndrome. Lancet. 2015;386(9996):913-27.Walker BR. Glucocorticoids and cardiovascular disease. Eur J Endocrinol. 2007;157(5):545-59.De Groot JW, Dogan F, van Koetsveld PM, et al. Pituitary tumors and visual field defects: pathophysiology and diagnosis. J Clin Endocrinol Metab. 2011;96(5):1273-84.Raff H, Carroll TB. Cushingand;rsquo;s syndrome: from physiological principles to diagnosis and clinical care. Endocr Rev. 2015;36(2):159-91.Findling JW, Raff H. Cushingand;#39;s Syndrome: Important Issues in Diagnosis and Management. J Clin Endocrinol Metab. 2006;91(10):3746-54.Pivonello R, De Leo M, Cozzolino A, Colao A. The Treatment of Cushingand;rsquo;s Disease. Endocr Rev. 2015;36(4):385-486.Oldfield EH, Doppman JL, Nieman LK, et al. Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushingand;#39;s syndrome. N Engl J Med. 1991;325(13):897-905.Nieman LK, Biller BMK, Findling JW, et al. The diagnosis of Cushingand;#39;s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008;93(5):1526-40.Fleseriu M, Petersenn S, Zamorano JL, et al. Cushingand;rsquo;s Disease: Evidence-Based Treatment. Endocr Rev. 2021;42(2):158-93.Pivonello R, De Martino MC, De Leo M, et al. Advances in the diagnosis and management of Cushingand;rsquo;s disease. Lancet Diabetes Endocrinol. 2018;6(8):484-98.