dawnmedDawnMed Journal of Medical ScienceISVolume 2, Issue 4MultidisciplinaryEnglish2026NNY20261014Gastroenterology / HepatologySociodemographic and Comorbidity Profiles of Crohn's Disease Versus Ulcerative Colitis: A Cross-Sectional Analysis of the 2023–2024 National Health Interview SurveyEnglishY3847Hussam MohammedAlahmadi¹EnglishNMohammadAlageeli¹EnglishYYazeed NashiAlaufi¹EnglishYZiyad HamzahAlahmadi²EnglishYAdnan SalehAlqarni³EnglishYBader MusaadAlharbi¹EnglishYAhmed MohammedAljabri¹EnglishYAhmad SultanAlamri¹EnglishYNada NayefAlthbute⁴EnglishYAnas AbdulrahmanAlshotiry³EnglishY10.64039/djms.2026.2408Background: Crohn's disease (CD) and ulcerative colitis (UC) are the two main subtypes of inflammatory bowel disease (IBD) and are usually explored as a single entity, obscuring the specific sociodemographic and comorbidity patterns of each entity.Aim: To explore and compare the sociodemographic and chronic comorbidity patterns of United States (US) adults with a self-reported diagnosis of CD versus UC.Methods: This nationally representative, cross-sectional analysis utilized data from the 2023–2024 National Health Interview Survey (NHIS) on a total of 62,151 adults. The diagnosis of CD (n = 351) and UC (n = 861) was established by self-reported physician diagnosis and analyzed as two independent case groups, with each group compared against respondents without that diagnosis. Weighted chi-square and t-tests were utilized to compare sociodemographic and comorbidity profiles; univariate and multivariate regression analyses (adjusted for age, sex, body mass index, smoking status, and univariably significant comorbidities) were used to estimate crude and adjusted odds ratios (aOR) for 15 comorbidities.Results: In our sample, individuals with a diagnosis of CD and UC were significantly older than their comparators (52.6 ± 17.8 years and 56.8 ± 17.3 years, respectively, both p < 0.001). In unadjusted analysis, UC was significantly associated with female sex. Worse self-rated health and a significantly higher unadjusted prevalence of most comorbidities examined were reported by both groups. After multivariate adjustment, CD remained independently associated with asthma (aOR 1.41), psoriasis (aOR 1.96), hepatitis (aOR 2.41), arthritis (aOR 1.59), and colorectal cancer (aOR 2.14). UC, on the other hand, remained independently associated with eight comorbidities, including stroke, angina, dyslipidemia, psoriasis, depression, anxiety, arthritis, and chronic obstructive pulmonary disease (aORs 1.25–2.50). Obesity showed an independent association with lower odds of UC after adjustment (aOR 0.77), whereas the association with female sex was no longer significant (aOR 1.14).Conclusions: Both CD and UC showed a significant presence of chronic comorbidity, but their adjusted comorbidity profiles differed, with UC showing independent associations with more comorbidities than CD, although the two diseases were not compared directly. These findings support the importance of disease-specific approaches rather than combined ones in the screening of IBD patients.EnglishCrohn's disease; ulcerative colitis; inflammatory bowel disease; comorbidity; sociodemographic factors; National Health Interview Survey.https://dawnmed.com.sa/abstract?id=39References1619Gecse KB, Vermeire S. Differential diagnosis of inflammatory bowel disease: imitations and complications. Lancet Gastroenterol Hepatol. 2018;3(9):644and;ndash;53. doi:10.1016/S2468-1253(18)30159-6Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769and;ndash;78. doi:10.1016/S0140-6736(17)32448-0Dahlhamer JM, Zammitti EP, Ward BW, Wheaton AG, Croft JB. Prevalence of inflammatory bowel disease among adults aged and;ge;18 years and;mdash; United States, 2015. 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